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  In addition to p16 and ARF, this gene generates four other isoforms
  as a result of option splicing. This gene encodes two proteins, p16 and p14ARF,
  which are transcribed from the similar second and 3rd exons
  but substitute 1st exons: p16 from exon 1α and ARF
  from exon 1β. As a result, they are translated from distinctive reading frames and thus have totally distinct
  amino acid sequences. Aliases CDKN2A, CDK4I,
  CDKN2, CMM2, INK4, INK4A, Mlm, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4,
  P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF.
  16 inhibits cyclin dependent kinases four and 6 (CDK4
  and CDK6) and thereby activates the retinoblastoma (Rb) relatives of proteins, which block traversal
  from G1 to S-phase. 14ARF (recognized as p19ARF in the mouse) activates the p53 tumor suppressor.
  Both act as tumor suppressors by regulating the mobile cycle.
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